Perhaps the time-worn expression “having a gut feeling” holds more potency than any of us realized. Studies of the intestinal microflora reveal how disturbances in its biodiversity can affect everything from obesity and autoimmune diseases to chronic depression. As a follow-up to our article referencing the Mediterranean Diet and gut health, we will now delve deeper into the far-reaching effects of the gut microbiome.
The Gut-Microbiome, Inflammation, and Obesity
Systemic chronic low-grade inflammation, often associated with obesity, renders an individual prone to cardiovascular diseases and type 2 diabetes. Past research honed in on unregulated adipose tissue or insulin resistance as the main culprits in inflammation. However, systemic inflammation involves a complexity only recently studied and still somewhat of a mystery.
Chronic inflammation often presents in individuals consuming a high-fat diet; scientists now posit whether this condition appears as a prelude to obesity-related metabolic disorders, not an end product, since the gut microbiome appears substantially different in those living with autoimmune diseases, obesity and other metabolic disorders.
Considering the human gastrointestinal system receives first exposure to everything we ingest, the supposition exists that as diet affects the gut microflora, systemic inflammation might result. The medical community feels that a promising step rests on the premise that restoring gut microbiota composition (by dietary intervention, prebiotics, and probiotics) could mitigate disease.
To examine the relationship between food consumption and gut dysfunction, a group of scientists placed subjects into two groups: one receiving a high-fat diet, one eating normal meals. Data revealed that the higher fat diet aligned with significant changes in the gut microbiome, intestinal permeability, and systemic low-grade inflammation. Glucose tolerance also plummeted.
Armed now with the strong conviction that one’s gut microbiome plays a key role in the appearance of inflammation and altered metabolic pathways, future studies plan to assess whether probiotics might serve as an important tool in both treatment and prevention of obesity and Type 2 diabetes.
The Gut Microbiome and Organ Cross-Talk
Upon closer inspection, scientists noted the presence of what they call “bi-directional cross-talk” between host microflora and the endocrine system, where autoimmune dysfunction often originates. The immune system participates in such cross-conversation.
Gut microbiota not only regulate systemic immunity; the immune system also contributes to the biodiversity of the microflora. This mutual communication between the microbiota and the immune system underscores how the human body’s health relies on “outside-in” and “inside-out” systems of checks and balances.
The ever-evolving studies on intestinal microflora now demonstrate that inflammation within the central nervous system also stems from our gut health. Once again, the bi-directional communication occurs, referred to as the “brain axis signaling pathways”.
A healthy gut landscape can transmit brain signals through connections involving neurogenesis, neural transmission, and behavioral control. Disruption to the indigenous gut microbiota renders these pathways dysregulated; the resulting altered permeability negatively affects the blood-brain barrier. It seems feasible then to see how gut microflora has a powerful impact on mental health, most notably stress, depression, and anxiety disorders. As a prime example, over 20% of individuals living with chronic inflammatory bowel disease suffer from some manner of sleep disturbances and depression.
The “Inside-Outside” Scoop
Clients often open up to us about how they “do everything right” with regard to lifestyle and diet, yet still cannot achieve their goals. Educating them about the far-reaching effects of their gut microbiome could shed some light on their predicament. Trainers have the ability to guide clients, reminding them how healthy insides keep us fit and disease-free.